University of Southern California

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Clinical Trial


Brinton Laboratory

The goals of our research are to discover why the aging brain develops Alzheimer’s disease and based on this knowledge develop strategies to prevent, delay and treat Alzheimer’s. To achieve these goals, we have investigated mechanisms of bioenergetic and regenerative aging of the brain.

The brain is the most energetically demanding organ of the body and as such is acutely vulnerable to reduction in fuel supply, metabolic capacity and mitochondrial generation of ATP. Bioenergetic aging of the brain is a potential driver of the lifetime risk of developing Alzheimer's disease.

Our research has demonstrated that ovarian steroids and neurosteroids are key mechanistic regulators of the bioenergetic and regenerative systems of the brain. Moreover, loss of ovarian hormones leads to activation of a sequence of compensatory responses that ultimately lead to development of Alzheimer's pathology.

Translationally, bioenergetic and regenerative pathways activated by ovarian steroids  and neurosteroids provide the basis for personalized interventions that target stages of bioenergetic aging in both the female and male brain to prevent, delay and treat Alzheimer's disease. 

Research in my laboratory uses a spectrum of investigative strategies including genomic, biochemical, cellular, imaging, translational and clinical studies in human.


USC Professors Recieve NIH Funding for Clinical Trial of Alzheimer's Drug

September 18, 2013 -- USC Professors Roberta Diaz Brinton of the USC School of Pharmacy and Lon Schneider of the Keck School of Medicine of USC are principal investigators of a newly funded study from the National Institutes of Health, aimed at testing promising drugs for the prevention of Alzheimer’s disease.

The USC project, “Allopregnanolone Regenerative Therapeutic for MCI/Alzheimer’s: Dose Finding Phase 1,” is the first clinical trial to evaluate the safety and tolerability of using allopregnanolone, a natural brain steroid, in treating mild cognitive impairment and Alzheimer’s disease, as part of an intensified national effort to find effective interventions for the degenerative brain disease.

The study is among the first to be developed with direction from the 2012 NIH "Alzheimer’s Disease Research Summit: Path to Treatment and Prevention," and reflects research goals in the "National Plan to Address Alzheimer’s Disease," according to the announcement from the National Institutue of Aging, the lead agency within the NIH for Alzheimer's research.

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LA Magazine names Dr. Roberta Diaz Brinton 2014 Woman of the Year

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The Alzheimer’s researcher tells students: If you want to change the world, become a scientist

September 16, 2014 Shayna Rose Arnold

 

The Alzheimer’s researcher tells students: If you want to change the world, become a scientist

- See more at: http://www.lamag.com/lawomanarticle/roberta-diaz-brinton-m-d/#sthash.dhIGPU2q.dpuf

 

 




University of Southern California