The goals of our research are to discover why the aging brain develops Alzheimer’s disease and based on this knowledge develop strategies to prevent, delay and treat Alzheimer’s. To achieve these goals, we have investigated mechanisms of bioenergetic and regenerative aging of the brain.
The brain is the most energetically demanding organ of the body and as such is acutely vulnerable to reduction in fuel supply, metabolic capacity and mitochondrial generation of ATP. Bioenergetic aging of the brain is a potential driver of the lifetime risk of developing Alzheimer's disease.
Our research has demonstrated that ovarian steroids and neurosteroids are key mechanistic regulators of the bioenergetic and regenerative systems of the brain. Moreover, loss of ovarian hormones leads to activation of a sequence of compensatory responses that ultimately lead to development of Alzheimer's pathology.
Translationally, bioenergetic and regenerative pathways activated by ovarian steroids and neurosteroids provide the basis for personalized interventions that target stages of bioenergetic aging in both the female and male brain to prevent, delay and treat Alzheimer's disease.
Research in my laboratory uses a spectrum of investigative strategies including genomic, biochemical, cellular, imaging, translational and clinical studies in human.
The Alzheimer’s researcher tells students: If you want to change the world, become a scientist
The Alzheimer’s researcher tells students: If you want to change the world, become a scientist- See more at: http://www.lamag.com/lawomanarticle/roberta-diaz-brinton-m-d/#sthash.dhIGPU2q.dpuf
Monday, February 9, 2015 to Tuesday, February 10,
National Institutes of Health
The goal of the Alzheimer's Disease Research Summit 2015 is to continue the development of an integrated multidisciplinary research agenda to address critical knowledge gaps and accelerate discovery and delivery of successful interventions for people at all stages of the disease. Toward that goal, the 6-session agenda brings together speakers and panelists from different disciplines in academia, industry, federal agencies, private foundations, and public advocacy groups working on Alzheimer's and other complex diseases in an effort to share ideas and most effectively move research forward. Roberta Diaz Brinton, PhD, chaired a session and presented “Understanding Bioenergetic Compromise and Gender-Related Phenotypes of AD Risk,” to view online Videocast click here.